8 Drugs That May Interact With Cannabis

Cannabis has genuine mental and physical effects that can react with other medications. Although there is an insufficient amount of research on cannabis and drug interactions, it is important to pay attention if you are taking any of the following drugs: Cannabis Drug Reactions


Cannabis can lower your blood sugar levelsMayo Clinic recommends, “people taking drugs for diabetes by mouth or insulin should be monitored closely” when adding cannabis to their health care protocol, and that “medication adjustments may be necessary.”

High Blood Pressure Medication

Cannabis has been known to lower blood pressure. When taking medical cannabis with other medications that lower blood pressure, Cleveland Clinic suggests undergoing “frequent assessments of your heart function, including heart rate, blood pressure and rhythm.”


The University of Washington’s Alcohol & Drug Abuse Institute suspects that taking cannabis may intensify the negative side effects of antidepressants. Talk to your doctor if you experience dizziness, anxiety, panic, drowsiness, nausea, confusion, or have an abnormally fast heartbeat.

Anti-Inflammatory Drugs

Some sources point out that cannabis can increase your risk of bleeding when combined with over the counter anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®), naproxen (Naprosyn®, Aleve®), and aspirin. While this may be true, we were not able to verify this information with clinical research or laboratory studies.

Blood Thinners

We were not able to find any studies indicating that cannabis can increase the chance of bleeding, but Mayo Clinic suggests taking caution when combining cannabis and blood thinners or antiplatelet drugs, including warfarin (Coumadin®), heparin, and clopidogrel (Plavix®).

Benzodiazepines and Barbiturates

According to Mayo Clinic, cannabis may increase drowsiness caused by benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®) and barbiturates such as phenobarbital. Narcotics such as codeine, some antidepressants, and alcohol can also result in severe drowsiness. Try a sativa strain to help you stay alert and focussed or schedule a time for a nap during your daily regime.

Marinol and Cesamet

The psychoactive effects of synthetic THC pharmaceuticals, such as Marinol and Cesamet, can become uncomfortably intensified when combined with natural cannabis.

Herbal substances

Read our piece on cannabis and herbs to learn how natural medications and herbal supplements can interact with cannabis.

Have you experienced any reactions when combining cannabis with other medications? Please share by commenting below.

Sienna Bates
Sienna lives in New York, New York and recently studied at Brown University in Providence, RI. She is one of the premier editors helping ensure top-shelf quality guidelines are met with integrity and our philosophy. She now works as an after school enrichment center teacher to help students complete assignments and helps cover current cannabis news event updates.


Please enter your comment!
Please enter your name here



Latest Cannabis Guides

Best CBD Gummies: Top 25 Product Rankings for 2020 to Review

Finding the best CBD gummies in 2020 requires proper research, personal due diligence and actual investigative analysis to ensure quality, potency and effectiveness. Yes, CBD...

Best CBD Drinks: Top 100 CBD Oil-Infused Beverages in 2020

Best CBD Drinks in 2020: Top CBD Waters, Teas, Kombuchas, Coffees and Sports Nutrition Beverages CBD drinks. Finally! After decades of marijuana prohibition, and years of...

Top 11 Best CBD Pet Products in 2020

Everyone’s talking about the health benefits of CBD oil and touting its health benefits. However, did you know that there are CBD products that...